Do you want to save your time? MOSAIC HOUSE recommends an airport shuttle service to and from the Prague airport. More info and bookings here.
Take bus 119 to the last stop, Nadrazi Veleslavin Metro Station (Line A – Green Line). Take the underground metro six stops to Mustek. Follow the transfer signs to Line B (Yellow Line). Take the metro line B one stop to Narodni trida. Exit the metro and take one of the trams 18, 22 or 23 one stop to Karlovo namesti. Cross the street and walk back until you see the SONY store on the corner. Make a left onto Odborů street (beside the Sony store). At the end of the street you will see MOOo white historical building at Myslíkova 22.
Exit the train station and walk through the park, cross the street and make a right to Jeruzalémská, walk down the street (pass a synagogue). get on tram number 5 in the direction of Barrandov (tram goes through Wenceslas Square). Get off at Myslíkova (4 stops) and cross the street. At the end of the street you will see MOOo building.